Sheng et al reported a nomogram for predicting a high-grade cervical lesion in a woman. The authors are from Huazhong University of Science and Technology in China.
Parameters:
(1) ThinPrep cytological test (TCT), from 1 to 5
(2) HPV type, from 1 to 5
(3) white acetate epithelium
(4) atypical vessels
(5) mosaic pattern
TCT Status
TCT Number
NILM
1
ASC-US or AGC
2
LSIL
3
ASC-H
4
HSIL, SCC
5
HPV Status
HPV Number
negative
1
high risk HPV
2
HPV 16
3
HPV 18/45
4
combined multiple HPV
5
points for TCT =
= (25 * (TCT)) - 25
points for HPV =
= (14.2 * (HPV)) - 14.2
Parameter
Finding
Points
white acetate epithelium
no
0
yes
44.5
atypical vessels
no
0
yes
51.5
mosaic
no
0
yes
20
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 272.7
• The presence of HSIL or SCC in a ThinPrep would be a good indicator of a high-grade lesion.
value of X =
= (0.02663 * (score)) - 4.124
risk of high-grade lesion =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curves is 0.85.
To read more or access our algorithms and calculators, please log in or register.
