Models of Callegaro et al for a Patient with a Localized Soft Tissue Sarcoma of an Extremity: Distant Metastases

Description

Callegaro et al reported 2 nomograms for predicting outcomes of a patient with a soft tissue sarcoma of an extremity. One nomogram predicts distant metastases. The authors are from multiple institutions in Europe, the United States and Canada.

Patient selection: localized soft tissue sarcoma of an extremity

Parameters:

(1) maximum diameter in cm

(2) histologic grade

(3) histologic type

Diameter	Points
1 to 10	(-0.4363 * ((diam)^2)) + (12.13 * (diam)) - 12.56
10 to 35	(-0.01046 * ((diam)^2)) + (1.85 * (diam)) + 47.79

Parameter	Finding	Points
grade	Grade 1	0
	Grade 2	43.1
	Grade 3	58.3
type	myxoid liposarcoma	6.1
	undifferentiated pleomorphic sarcoma (UPS)	15.5
	dedifferentiated or pleomorphic liposarcoma	7.6
	myxofibrosarcoma	0
	MPNST	18.6
	other	24.1
	leiomyosarcoma	39.5
	synovial sarcoma	29.4
	vascular sarcoma	39.5

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 238.8

Score	Value of X
2 to 123	(0.03086 * (score)) - 4.718
123 to 196	(0.0003295 * ((score)^2)) - (0.05389 * (score)) + 0.8088

Total Score	10-Year Risk Distant Metastases
<= 196	1/ (1 + EXP((-1) * X))
> 196	> 95%

Performance:

• The area under the ROC curve is 0.76.

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Models of Callegaro et al for a Patient with a Localized Soft Tissue Sarcoma of an Extremity: Distant Metastases

Description

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