Chen et al reported models for predicting the severity of various stages of hemorrhagic fever with renal syndrome (HFRS) due to a Hantavirus infection. Changes shown by a patient may predict clinical deterioration. The authors are from Xi'an Jiaotong University, Fudan University and Shanghai University of Traditional Chinese Medicine in China.
Patient selection: nonfebrile stage of hantavirus-associated hemorrhagic fever with renal syndrome
Predictors of severe disease during the febrile stage:
(1) reduced eGFR (positive value, OR 15.7)
(2) lower serum sodium (OR 0.85)
(3) higher urine conductivity (OR 1.46)
(4) maximum renal cystatin C (OR 1.8)
(5) elevated serum enzymes for myocardial damage (OR 1.00, with better coefficient 0.001)
where:
• The low serum potassium and elevated urine conductivity suggests urine sodium wastage. Measuring urine sodium might be informative.
To read more or access our algorithms and calculators, please log in or register.
