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Models of Christianen et al for Swallowing Dysfunction After Chemoradiation for Head and Neck Cancer: Problems Swallowing Solid Food

Description

Christianen et al developed several predictive models for swallowing dysfunction following chemoradiation for head and neck cancer. One model predicts problems while swallowing liquids. The authors are from University Medical Center Groningen and VU University Medical Center Amsterdam in The Netherlands.


Patient selection: head and neck cancer after chemoradiation

 

Outcome: problems swallowing solid food

 

Parameters:

(1) mean radiation dose to superior pharyngeal constrictor muscle (PCM) in Gray (Gy)

(2) mean radiation dose to supraglottic larynx in Gray (Gy)

(3) age (18 to 65 vs > 65 years of age)

 

Age

Points

18 to 65 years

0

> 65 years

1

 

X =

= (0.049 * (mean dose to superior PCM)) + (0.048 * (mean dose to supraglottic larynx)) + (0.795 * (points for age)) – 6.89

 

probability of problems swallowing solid foods =

= 1 / (1 + EXP((-1) * X))

 

Performance:

• The area under the ROC curve was 0.78.


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