Modified GAP Index of Kobayashi et al for Predicting an Acute Exacerbation of Idiopathic Pulmonary Fibrosis (IPF) in a Patient with Non-Small Cell Lung Cancer (NSCLC)

Description

Kobayashi et al used a modified GAP index to evaluate patients with idiopathic pulmonary fibrosis (IPF) and non-small cell lung cancer (NSCLC). The score correlates both with survival and exacerbations of the IPF. The authors are from Shizuoka Cancer Center in Japan.

Patient selection: interstitial lung disease

Outcome: mortality

The modified GAP index has 3 of the 4 original parameters in the index of Ley et al, with removal of DLCO as percent of predicted (P). Testing for DLCO is not routinely performed since it exhausts the patient.

Parameters:

(1) gender (G)

(2) age in years (A)

(3) FVC as percent of predicted (P)

Parameter	Finding	Points
gender	female	0
	male	1
age	<= 60 years	0
	61 to 65 years	1
	> 65 years	2
FVC	> 75% of predicted	0
	50 to 75% of predicted	1
	< 50% of predicted	2

total score =

= SUM(points for all 3 parameters))

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the prognosis.

Total Score	Stage	Acute Exacerbation at 12 Months
0 to 3	Stage I	30%
4 or 5	Stage II	82%

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Modified GAP Index of Kobayashi et al for Predicting an Acute Exacerbation of Idiopathic Pulmonary Fibrosis (IPF) in a Patient with Non-Small Cell Lung Cancer (NSCLC)

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