A modified version of the Rose index (see 04.13.02) was used by the Canadian Apheresis Group to evaluate patients with thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS).
Parameters:
(1) neurological findings
(2) serum creatinine at presentation, indicative of renal impairment
(3) platelet count
(4) hemoglobin
Parameter
Finding
Points
neurological findings
absent
0
present
1
serum creatinine
< 132 µmol/L (no renal impairment)
0
132 - 221 µmol/L
1
> 221 µmol/L
2
platelet count
> 100,000 per µL
0
20,000 - 100,000 per µL
1
< 20,000 per µL
2
hemoglobin
> 12.0 g/dL
0
9.0 - 12.0 g/dL
1
< 9.0 g/dL
2
where:
• The changes from the original index include simpler handling of the neurological findings and renal impairment.
total score =
= SUM(points for all 4 parameters
Interpretation:
• minimum score: 0
• maximum score 7
• The higher the score the more severe the disease.
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