Glucose-6-Phospate dehydrogenase (G6PD) deficiency may present as neonatal hyperbilirubinemia.
Patient selection: neonatal hyperbilirubinemia
Clinical features may include:
(1) family history of G6PD deficiency
(2) hemolytic anemia
(3) onset after exposure to methanol (in powder used to treat the umbilical cord) or a drug that can trigger hemolysis in G6PD deficiency (icterogenic agents)
(4) exclusion of other causes of hyperbilirubinemia (negative direct antiglobulin test, etc)
Testing:
(1) deficient enzyme activity on red blood cell testing
(2) endogenous production of carbon monoxide (an index of heme catabolism)
Complications:
(1) bilirubin-induced neurologic dysfunction
To read more or access our algorithms and calculators, please log in or register.
