Han et al reported a nomogram for predicting overall survival for a patient with diffuse large B-cell lymphoma (DLBCL). This can help to identify a patient who may require more aggressive management. The authors are from National Cancer Center, Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing.
Patient selection: diffuse large B-cell lymphoma
Parameters:
(1) age in years
(2) ECOG performance status
(3) Ann Arbor stage
(4) expression of CD5
(5) Ki-67 index in percent
(6) serum LDH concentration
(7) serum beta-2 microglobulin concentration
Parameter
Finding
Points
age in years
<= 60 years
0
> 60 years
25
ECOG PS
0 or 1
0
2 to 4
60
Ann Arbor stage
I
0
II
33
III
67
IV
100
CD5 expression
negative
0
positive
81
Ki-67 index
< 90%
0
>= 90%
46
LDH
normal
0
elevated
44
beta-2 microglobulin
normal
0
elevated
54
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 410
• The higher the score the worse the overall survival.
