Nomogram of Liu et al for Recurrence of an Early Hepatocellular Carcinoma After Radiofrequency Ablation (RFA)

Description

Liu et al developed a nomogram for evaluating a patient with early-stage hepatocellular carcinoma. This can help to decide if a patient can be managed by radiofrequency ablation or requires surgical resection. The authors are from Taipei Veterans General Hospital, National Yang-Ming University and the University of Nevada.

Patient selection: early hepatocellular outcome, 1 to 3 tumors, largest 5.0 cm

Outcome: recurrence-free survival (time frame not clearly specified but appears to be up to 3 years) after radiofrequency ablation

Significance: lower recurrence-free survival would favor surgical resection

Parameters:

(1) number of tumors

(2) diameter of largest tumor in cm

(3) serum albumin in g/dL

(4) MELD score

(5) platelet count per microliter

Parameter	Finding	Points
number of tumors	1	0
	2	4.3
	3	10
diameter in cm	<= 2.0 cm	0
	2.1 to 3.0 cm	4
	3.1 to 5.0 cm	6.3
serum albumin	>= 4.0 g/dL	0
	< 4.0 g/dL	3.8
MELD	< 8	0
	>= 8	3
platelet count	>= 150,000 per µL	0
	< 150,000 per µL	3

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 26.1

• The higher the score the worse the recurrence-free survival.

Total Score	Recurrence-Free Survival
0 to 23.8	(-0.0002703((score)^2)) - (0.02155 (score)) + 0.8444
> 23.8	< 19%

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Nomogram of Liu et al for Recurrence of an Early Hepatocellular Carcinoma After Radiofrequency Ablation (RFA)

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