Zhang et al reported a nomogram for a patient with nonmetastatic nasopharyngeal carcinoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma, Sun Yat-Sen and First Affiliated Hospital of Guangdong Pharmaceutical University in China.
Patient selection: patient with non-metastatic (M0) nasopharyngeal carcinoma
Parameters:
(1) age in years
(2) T status
(3) N states
(4) plasma EBV DNA load in copy/mL
(5) serum albumin in g/dL
(6) serum LDH in U/L
Parameter
Finding
Points
age
< 18 years
7.3
18 to 29 years
0
30 to 39 years
15.5
40 to 49 years
23.6
50 to 59 years
43.5
>= 60 years
84.9
T status
T1
0
T2
21.2
T3
35.3
T4
73.4
N status
N0
0
N1
43.7
N2
77.6
N3
100
EBV DNA load
< 2,000 copy/mL
0
>= 2,000 copy/mL
37.4
serum albumin
>= 4 g/dL
0
< 4 g/dL
18.7
serum LDH
< 245 U/L
0
>= 245 U/L
26.6
total score =
= SUM(points for all 6 parameters)
Interpretation:
• minimum score: 0
• maximum score: 341
• The higher the score the worse the survival.
Score
5-Year Overall Survival
<12.59
> 98%
12.59 to 393.34
X = 4.254 - (0.015 * (score))
percent OS = 1/(1+EXP((-1) * X))
> 393.34
< 40%
Performance:
• The area under the ROC curve is 0.72.
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