Raut et al developed two nomograms for patients with a retroperitoneal sarcoma. One of these nomograms predicts overall survival. The authors are from multiple institutions in the North America and Europe.
Patient selection: retroperitoneal sarcoma, from 10 to 90 years of age
Outcome: 7-year overall survival (OS)
Parameters:
(1) tumor diameter in centimeters
(2) FNCLCC grade
(3) histologic subtype
(4) multifocality
(5) age
(6) extent of resection
Tumor Diameter |
Points |
0 to 20 cm |
(-0.037635 * ((size)^2)) + (3.3559 * (size)) - 0.60102 |
20 to 30 cm |
(0.392 * (size)) + 43.12 |
30 to 80 cm |
(-0.0006125 * ((size)^2)) - (0.075425 * (size)) + 57.76 |
Age in Years |
Points |
10 to 50 years |
(-0.37255 * (years)) + 18.373 |
50 to 60 years |
(0.29412 * (years)) - 14.706 |
60 to 90 years |
(1.1001 * (years)) - 63.954 |
Parameter |
Finding |
Points |
FNCLCC grade |
Grade 1 |
0 |
|
Grade 2 |
74.5 |
|
Grade 3 |
100 |
histologic subtype |
solitary fibrous tumor |
0 |
|
malignant peripheral nerve sheath tumor |
5.9 |
|
liposarcoma, dedifferentiated |
7.8 |
|
leiomyosarcoma |
20 |
|
liposarcoma, well-differentiated |
41.2 |
|
unclassified, undifferentiated pleomorphic |
25.5 |
|
other |
21.6 |
multifocal |
no (unifocal) |
0 |
|
yes |
26.5 |
extent of resection |
complete |
0 |
|
incomplete |
16.7 |
total score =
= SUM(points for all 6 parameters)
Interpretation:
• maximum score: 275.3
Total Score |
7-year overall survival |
< 19.4 |
> 99%% |
19.4 to 206 |
see X below |
> 206 |
< 1% |
X =
= (-0.000001806 * ((score)^3)) + (0.00045265 * ((score)^2)) - (0.065888 * (score)) + 5.764
probability =
= 1 / (1 + EXP((-1) * X))
Specialty: Hematology Oncology