Saokaew et al developed a score for evaluating patients with the metabolic syndrome (MetS or MS) for non-alcoholic fatty liver disease (NAFLD). The authors are from multiple institutions in Thailand, the United States and Australia.
Patient selection: metabolic syndrome
Parameters:
(1) serum ALT in U/L
(2) serum AST to ALT ratio
(3) body mass index (BMI) in kilograms per square meter
(4) central obesity
(5) type 2 diabetes mellitus
Parameters
Findings
Points
serum AST
< 40 U/L
0
>= 40 U/L
2
AST to ALT ratio
< 1
0
>= 1
1
BMI
< 25
0
>= 25
1.5
central obesity
no
0
yes
1
type 2 diabetes
no
0
yes
1
where:
• The BMI cut-point is not as high as one might expect.
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6.5
Score
Risk for NAFLD
Percent NAFLD
0 to 2.5
low
48%
3 to 4.5
moderate
82%
>= 5
high
94%
Performance:
• The area under the ROC curve is 0.77.
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