Pericas et al reported for criteria for outpatient parenteral antibiotic therapy (OPAT) for infective endocarditis. The authors are from multiple institutions in Spain.
Patient selection: infective endocarditis
Inclusion criteria - both of the following:
(1) overcome the acute critical phase
(2) no exclusion criteria
Exclusion criteria:
(1) liver cirrhosis Child B or C
(2) active intravenous drug user
(3) severe CNS emboli
(4) undrained large renal and/or splenic abscess
(5) vertebral abscess requiring neurosurgery
(6) periannular complications or other severe conditions requiring surgery but unable to perform
(7) severe postsurgical complications
(8) very difficult-to-treat micro-organism
Severe CNS emboli - any of the following: fixed neurological deficit, hemorrhagic infarct, large infarct > 2 cm, > 3 emboli.
Severe conditions in item 6 include: perivalvular abscess, fistula, perforation, pseudoaneurysm cardiac tamponade
