Kidney stones are relatively uncommon in children. A pediatric patient with Cushing's disease may present with nephrolithiasis. Kidney stones are relatively common in adults with Cushing's disease.
Patient selection: child with nephrolithiasis
Predisposing factors for stone development: hypercalcuria secondary to increased bone resorption
Other manifestations may include:
(1) obesity
(2) hypertension
(3) diabetes
(4) striae
(5) hirsutism
(6) reduced height for age
Laboratory findings:
(1) elevated urine free cortisol
(2) elevated urinary calcium to creatinine ratio
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