Sachdev et al reported a mortality risk score for a patient with sickle cell disease. The authors are from the National Heart, Lung and Blood Institute at NIH.
Patient selection: sickle cell anemia
Parameters:
(1) tricuspid regurgitation velocity (TRV) in m/s
(2) body mass index (BMI) in kg per sq meter
(3) heart rate in beats per minute
(4) mitral E velocity in cm/s
(5) right atrial pressure in mm Hg
(6) serum alkaline phosphatase in U/L
(7) septal thickness in mm
(8) age in years
(9) blood urea nitrogen (BUN) in mg/dL
(10) serum NT-proBNP in pg/mL
Data from echocardiography
|
Parameter
|
Finding
|
Points
|
|
TRV
|
<= 3 m/s
|
0
|
|
|
> 3 m/s
|
1
|
|
mitral E velocity
|
<= 80 cm/s
|
1
|
|
|
> 80 cm/s
|
0
|
|
right atrial pressure
|
<= 5 mm Hg
|
0
|
|
|
> 5 mm Hg
|
1
|
|
septal thickness
|
<= 10 mm
|
0
|
|
|
> 10 mm
|
1
|
Data without echocardiography
|
Parameter
|
Finding
|
Points
|
|
BMI
|
< 35 kg per sq m
|
0
|
|
|
>= 35 kg per sq m
|
1
|
|
heart rate
|
<= 85 bpm
|
0
|
|
|
> 85 bpm
|
1
|
|
serum alkaline phosphatase
|
<= 90 U/L
|
0
|
|
|
> 90 U/L
|
1
|
|
age in years
|
<= 50 years of age
|
0
|
|
|
> 50 years of age
|
1
|
|
serum BUN
|
<= 20 mg/dL
|
0
|
|
|
> 20 mg/dL
|
1
|
|
NT-proBNP
|
< 160 pg/mL
|
0
|
|
|
>= 160 pg/mL
|
1
|
simple risk score =
= SUM(points for the first 9 parameters without NT-proBNP)
Interpretation:
• minimum simple score: 0
• maximum simple score: 9 (from online version at dir.nhibi.nih.gov_
|
Total Score
|
Risk
|
|
0 or 1
|
low
|
|
2 or 3
|
intermediate-1
|
|
4
|
intermediate-2
|
|
5 to 9
|
high
|
