medical decision support 1 medical decision support 2
Subscribe Sign In

Post-Resection Independent Predictive (PRIP) Score of Hung et al for Recurrence of Hepatocellular Carcinoma Associated with Hepatitis B Virus (HBV)

Description

Hung et al developed a score for evaluating a patient with hepatitis B virus-associated hepatocellular carcinoma (HCC) following resection of the tumor. This can help to identify a patient at risk for recurrence. The authors are from the University of Hong Kong, Queen Mary Hospital, and the Hospital Authority of Hong Kong.


 

Patient selection: HBV-related hepatocellular carcinoma following surgical resection

 

Outcome: recurrent hepatocellular carcinoma (HCC)

 

Parameters:

(1) lymphovascular invasion

(2) microsatellite lesions

(3) serum alpha-fetoprotein in ng/mL

(4) HBV anti-viral therapy prior to resection

(5) post-resection HBV copies in IU/mL at one month following tumor resection (viral load)

Parameter

Finding

Points

lymphovascular invasion

no

0

 

yes

1.01

microsatellite lesion(s)

no

0

 

yes

1.03

serum AFP

<= 100 ng/mL

0

 

> 100 ng/mL

0.43

HBV antiviral therapy

no

0

 

yes

-2.9

HBV viral load at 1 month following resection

<= 20,000 IU/mL

0

 

> 20,000 IU/mL

0.45

 

where:

• In the text the scoring says < 100 but context elsewhere is > 100.

 

PRIP score =

= SUM(points for all 5 parameters) - 0.45

 

Interpretation:

• minimum score: -3.35

• maximum value: 2.47

• The higher the score the greater the risk of recurrent hepatocellular carcinoma.

 

Score

Recurrence

-3.35 to 0

(3.46 * ((points)^2)) + (22 * (points)) + 35.15

0 to 2.47

(-6.777*((points)^2)) + (43.49 * (points)) + 34.38

 

Performance:

• The AUC was 0.68 for 1 year recurrence.

• The AUC was 0.75 for 3-year recurrence.

 


To read more or access our algorithms and calculators, please log in or register.

Specialty