Description

Vermont et al identified levels of serum chemokines that are predictive of poor survival in pediatric patients with meningococcal sepsis. These can help identify patients who may require more aggressive management. The authors are Erasmus MC-Sophia Children's Hospital in Rotterdam and the Netherlands Vaccine Institute.


 

Patient selection: pediatric patient (<= 18 years of age) with meningococcal sepsis

 

Types of chemokines:

(1) C

(2) CC (includes monocyte chemoattractant protein 1 and macrophage inflammatory 1 alpha)

(3) CXC (includes interleukin-8)

(4) CX3C

 

Chemokines that can distinguish survivors from nonsurvivors:

(1) monocyte chemoattractant protein 1 (MCP-1)

(2) macrophage inflammatory 1 alpha (MIP-1alpha)

(3) interleukin-6 (IL-6)

(4) interleukin-8 (IL-8)

Chemokine

Level Associated with Mortality

MCP-1

>= 65,407 pg/mL (65 ng/mL)

MIP-1alpha

>= 460 pg/mL

IL-6

>= 361,000 pg/mL (361 ng/mL)

IL-8

>= 85,427 pg/mL (85 ng/mL)

 

Performance:

• The sensitivity is 100%

• The specificity is 94-98%.

 


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