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Predicting the Need for Extracorporeal Membrane Oxygenation (ECMO) and Mortality in a Neonate with Congenital Diaphragmatic Hernia (CDH) Using the Model of Neff et al

Description

Neff et al used measurement of the fetal lung volume in a patient with congenital diaphgramatic hernia (CDH) to predict the need for extracorporeal membrane oxygenation (ECMO) and mortality. These measures can help to predict which neonates will require more aggressive management. The authors are from University Hospital Mannheim and the University of Heidelberg.


 

Patient selection: neonate with congenital diaphragmatic hernia (CDH)

 

Patient analysis: fetal lung volume in mL by magnetic resonance imaging (MRI), performed between 32 and 34 weeks of gestation

 

The lower the lung volume the greater the risk of mortality and need for ECMO.

 

X =

= 1.9039 - (0.1093 * (volume in mL))

 

probability of needing ECMO =

= 1 / (1 + EXP((-1) * X))

 

Y =

= 3.0513 - (0.2828 * (volume of mL))

 

probability of mortality =

= 1 / (1 + EXP((-1) * Y))

 


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