Parameters:
(1) white blood cell count per microliter
(2) percent lymphocytes in the differential count
absolute lymphocyte count per microliter =
= (white blood cell count) * (percent lymphocytes) / 100
Data of Shapiro et al:
(1) An absolute lymphocyte count < 1,000 per microliter was associated with a CD4 count < 200 per microliter with a negative predictive value of 0.81 and a positive predictive value of 0.91.
(2) An absolute lymphocyte count > 2,000 per microliter was associated with a CD4 count >= 200 per microliter. The negative predictive value for a lymphocyte count < 2,000 per microliter for a CD4 count < 200 per microliter was 0.95.
Data of Agrawal et al:
(1) An absolute lymphocyte count < 1,654 per microliter was associated with a CD4 count < 200 per microliter.
(2) Referenced 6 other studies with cut-offs ranging from 1,200 to 1,780.
Putting this data together:
|
Absolute Lymphocyte Count
|
Proobability CD4 Count < 200 per µL
|
|
< 1,000
|
high
|
|
1,000 to 1,499
|
moderate
|
|
1,500 to 1,999
|
low
|
|
>= 2,000
|
very low
|
