Lekovic et al reported a predictive score for distinguishing prefibrotic primary myelofibrosis (prePMF) from essential thrombocythemia. These 2 myeloproliferative disorders may have a similar presentation with thrombocytosis. The authors are from the University of Belgrade and Wroclaw Medical University.
Patient selection: either pre-fibrotic myelofibrosis or essential thrombocythemia
Parameters:
(1) age of the patient in years
(2) splenomegaly
(3) serum LDH concentration
Parameter
Finding
Points
age of the patient
< 60 years
0
>= 60 years
1
splenomegaly
no
0
yes
2
serum LDH
<= upper limit of normal
0
> upper limit of normal
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• A score >= 2 has a sensitivity of 0.70 and specificity of 0.82, with the highest Youden index. The positive predictive value of a score >= 2 is 0.70 in the training and 0.62 in the validation cohorts.
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