Ma et al reported a nomogram for predicting the risk of hemorrhagic transformation following thrombolytic therapy for a patient with an acute ischemic stroke. The authors are from Ningxia Medical University and affiliated hospitals.
Patient selection: acute ischemic stroke treated with thrombolytic agents
Parameters:
(1) systolic blood pressure in mm Hg
(2) NIHSS, from 0 to 30
(3) neutrophil to lymphocyte ratio (NLR)
(4) serum NT-proBNP, presumably µg/L (ng/mL)
points for systolic blood pressure =
= (0.4182 * (SBP)) - 41.828
points for NIHSS=
= 3.333 * (NIHSS)
points for NLR =
= (13.314 * (NLR)) - 6.657
points for NT-proBNP =
= 0.125 * (BNP)
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 339.2
value of X =
= (0.09257 * (score)) - 14.1
risk of hemorrhagic transformation =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.95.
