Adam et al identified factors associated with complete pathologic response to preoperative chemotherapy in a patient with liver metastases from a colorectal carcinoma. The authors are from Assistance Publique-Hopitaux de Paris Hopital Paul Brousse, Universite Paris-Sud at Villejuif and the University of Utrecht.
Complete pathologic response = complete absence of viable cancer cells on pathologic examination.
Various chemotherapeutic regimens were given (see Patient Selection, page 1636). Metastases to the liver were surgically resected.
Parameters:
(1) age of the patient
(2) maximum size of the metastases at diagnosis in cm
(3) serum CEA at diagnosis
(4) objective radiologic response
|
Parameter |
Finding |
Points |
|
age |
<= 60 years |
1 |
|
|
> 60 years |
0 |
|
size of the lesion |
<= 3 cm |
1 |
|
|
> 3 cm |
0 |
|
CEA |
<= 30 ng/mL |
1 |
|
|
> 30 ng/mL |
0 |
|
objective radiologic response |
no change or progression |
0 |
|
|
partial or complete |
1 |
|
Age |
Size |
CEA |
Response |
Complete Response |
|
0 |
0 |
0 |
0 |
0.2% |
|
0 |
0 |
0 |
1 |
0.6% |
|
0 |
0 |
1 |
0 |
0.9% |
|
0 |
0 |
1 |
1 |
3.4% |
|
0 |
1 |
0 |
0 |
0.5% |
|
0 |
1 |
0 |
1 |
1.9% |
|
0 |
1 |
1 |
0 |
2.7% |
|
0 |
1 |
1 |
1 |
9.8% |
|
1 |
0 |
0 |
0 |
0.7% |
|
1 |
0 |
0 |
1 |
2.6% |
|
1 |
0 |
1 |
0 |
3.6% |
|
1 |
0 |
1 |
1 |
12.7% |
|
1 |
1 |
0 |
0 |
2% |
|
1 |
1 |
0 |
1 |
7.5% |
|
1 |
1 |
1 |
0 |
10.3% |
|
1 |
1 |
1 |
1 |
30.9% |
Specialty: Hematology Oncology, Surgery, general
ICD-10: ,
