Patient selection: nonalcoholic fatty liver disease (NAFLD)
Outcome: portal hypertension
Portal hypertension can occur due to cirrhosis, Grade 4 hepatic fibrosis or severe fat accumulation
Predictors for portal hypertension if liver biopsy available:
(1) thrombocytopenia (platelet count < 150,000 per µL, odds ratio 8.1)
(2) hyperbilirubinemia (total serum bilirubin > 1.0 mg/dL, odds ratio 7.6)
(3) cirrhosis (odds ratio 8.4
(4) obesity (BMI >= 30 kg per square meter, odds ratio 2.5)
Predictors for portal hypertension if liver biopsy is not available:
(1) thrombocytopenia (platelet count < 150,000 per µL, odds ratio 16.9)
(2) hyperbilirubinemia (total serum bilirubin > 1.0 mg/dL, odds ratio 5.6)
(3) diabetes mellitus (odds ratio 3)
(4) hypoalbuminemia (serum albumin < 3.5 g/dL, odds ratio 3.9)
Predictors for esophageal varices:
(1) thrombocytopenia
(2) type 2 diabetes (fasting blood glucose >= 126 mg/dL or requiring treatment)
(3) splenomegaly by radiologic criteria
