van Nimwegen et al reported predictors of heart failure for a survivor of Hodgkin lymphoma. These can help to identify a patient who should be managed aggressively. The authors are from the Netherlands Cancer Institute, University of Oxford, the Netherlands Comprehensive Cancer Organization, Erasmus Medical Center and Leiden University.
Patient selection: survivor of Hodgkin lymphoma
Predictors:
(1) mean left ventricular dose of radiation in Gy
(2) any anthracycline therapy (OR 2.8)
Radiation Dose
Any Anthracycline
25-Year Cumulative Risk of Heart Failure
<= 15 Gy
no
4.4%
yes
11.2%
16 to 20 Gy
no
6.2%
yes
15.9%
>= 21 Gy
no
13.3%
yes
32.9%
Radiation Dose
Any Anthracycline
35-Year Cumulative Risk of Heart Failure
<= 15 Gy
no
7.2%
yes
not available
16 to 20 Gy
no
10.2%
yes
not available
>= 21 Gy
no
21.8%
yes
not available
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