A premenopausal woman treated for cancer may experience premature ovarian failure. A number of findings in the ovary and serum can help to identify these women.
Evaluation: usually performed in the early follicular phase
Parameter |
Finding Associated with Premature Ovarian Failure |
ovarian volume |
reduced; may be < 3 cubic cm |
number of antral follicles |
reduced |
serum FSH |
increases as reserve declines, with persistent elevation; may be affected by oral contraceptives |
serum inhibin B |
decrease parallels decline in egg supply |
serum anti-Mullerian hormone (AMH) |
decrease parallels decline in egg supply |
These findings may occur in conjunction with clinical features of menopause:
(1) amenorrhea
(2) hot flashes
(3) night sweats
(4) vaginal dryness
Purpose: To identify ovarian and biochemical findings that may indicate premature ovarian failure in a premenopausal woman being treated for cancer.
Specialty: Hematology Oncology, Obstetrics & Gynecology
Objective: adverse effects
ICD-10: T45.1,