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Prognostic Combination Models of Louvet et al for Alcoholic Hepatitis: Lille Score and Maddrey Discriminant Function

Description

Louvet et al modeled combinations of the dynamic Lille score with other more static scores in patients with alcoholic hepatitis. One combination involved the Lille score and Maddrey Discriminant Function (DF). The authors are from multiple institutions in Europe, Korea and the United States.


Patient selection: alcoholic hepatitis

 

Parameters:

(1) Lille score

(2) Maddrey discriminant function (DF)

 

S =

= 0.985 * ((2.5373 * ((Lille model) - 0.4195)) + (0.0095 * ((MDF) - 61.8519)))

 

mortality rate at 2 months =

= (1 - (0.8062^EXP(S))) * 100

 

mortality rate at 6 months =

= (1 - (0.7091^EXP(S))) * 100

 

Performance:

• The Akaike information criterion was 1313.


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