Prognostic Factors in Gestational Trophoblastic Disease

Patients with Gestational trophoblastic disease (GTD) can be divided into good and poor prognostic groups based on clinical and laboratory findings.

Prognostic factors:

(1) duration of disease in months

(2) pretherapy serum HCG

(3) status of metastases

(4) features of preceding pregnancy

Prognostic Indicators	Good	Poor
duration in months	<= 4	> 4
pretherapy serum ß-HCG	<= 40,000	> 40,000 IU/L
metastases	neither brain or liver	brain or liver
preceding pregnancy	abortion, ectopic, hydatidiform mole	term pregnancy
previous chemotherapy for the GTD	no	yes

Interpretation:

• good prognosis: no poor prognostic indicators found

• poor prognosis: any of the poor prognostic indicators, with worsening of prognosis as number of indicators increases

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