Prognostic Factors in Osteogenic Sarcoma of the Jaws

Description

Osteogenic sarcoma involving the maxilla or mandible is a rare neoplasm that is often mistaken for an odontogenic infection. Certain clinical features are associated with the patient's prognosis. The authors are from the Massachusetts General Hospital in Boston.

Patients studied: 30 cases of osteosarcoma of the jaws.

Factor	Good Prognosis	Poor Prognosis
age	younger	older
clinical features		numbness
time to diagnosis	short	delayed
treatment	definitive surgery with aggressive adjuvant therapy (4 or more agents)	palliative radiation or chemotherapy without surgery
surgical margins	tumor > 5 mm from margin	tumor <= 5 mm from margin; margin positive
metastases	absent	present

A history of trauma at the primary tumor site was associated with a decreased disease-free survival.

The average age of survivors was 27 years, while that of nonsurvivors was 40 years. However, the number of patients is relatively small and the range was from 4 to 84.

Grade was not found to be statistically correlated with survival, but only 2 of the 30 tumors was Grade 1, with 17 Grade 2 and 11 Grade 3 tumors.

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Prognostic Factors in Osteogenic Sarcoma of the Jaws

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