Akhtar et al identified prognostic factors in patients with relapse refractory multiple myeloma treated with CAR-T therapy.The authors are from Medical College of Wisconsin, University of Missouri, and Moffitt Cancer Center.
Patient selection: relapse refractory multiple myeloma treated with CAR-T therapy
Parameters
(1) Glasgow Prognostic Score (GPS), based on serum albumin and serum CRP
(2) ECOG performance status
(3) extramedullary disease
(4) bone marrow burden
Parameters
Findings
Points
Glasgow Prognostic Score
0 or 1 (low or intermediate risk)
0
2 (high risk)
1
ECOG performance
0 or 1
0
> 2
1
extramedullary disease
absent
0
present
1
bone marrow burden
<= 50%
0
> 50% (high)
1
number of poor prognostic factors =
= SUM(points for all of the parameters)
Interpretation:
• minimum number of prognostic factors: 0
• maximum number of prognostic factors: 4
• These are associated with high-grade toxicity and worse overall survival.
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