Carli et al identified prognostic factors for pediatric patients with metastatic rhabdomyosarcoma. These can help identify patients who may benefit from more aggressive management. The authors are from the multiple university hospitals in Europe.
Patient selection: pediatric patients from 3 months to 18 years of age with metastatic rhabdomyosarcoma
Parameters:
(1) age of the patient in years
(2) primary tumor site
(3) metastases to bone and/or bone marrow
Parameter
Favorable
Unfavorable
age
1 - 9 years of age
< 12 months or >= 10 years
primary tumor site
genitourinary except prostate or bladder; head and neck except parameningeal
other sites
metastases to bone
absent
present
total number of unfavorable factors =
= SUM(number of unfavorable findings)
Interpretation:
• minimum number of unfavorable findings: 0
• maximum number of unfavorable findings: 3
• The presence of 0 or 1 unfavorable findings was associated with a better prognosis than the presence of 2 or 3 unfavorable findings.
Group
Probability of 5 Year Overall Survival
Probability of 5 Year Event Free Survival
favorable
47%
40%
unfavorable
9%
7.5%
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