Janssen et al evaluated patients with extrahepatic portal vein thrombosis. They identified prognostic factors affected overall survival. The authors are from multiple institutions in the Netherlands.
Patient selection: extrahepatic portal vein thrombosis
Outcome: overall survival
Prognostic factors associated with worse survival from the multivariate analysis:
(1) older age (relative risk 5.8 if > 60 years; 2.6 if 40 to 60 years)
(2) malignancy (relative risk 8.1)
(3) absence of abdominal inflammation (peritonitis, etc; relative risk 4.6)
(4) cirrhosis (relative risk 3.9)
(5) mesenteric vein thrombosis (relative risk 2.9)
(6) serum albumin < 35 g/L (relative risk 3.2)
(7) serum ALT >= 30 U/L (relative risk 1.9)
The survival is worse as the number of negative prognostic findings increase. The prognosis is fair (75% 10 year survival) for a patient without malignancy and without cirrhosis.
