Prognostic Factors of Raschilas et al for an Adult Patient with Herpes Simplex Virus (HSV) Encephalitis

 

Poor outcome: death or severe disability at 6 months

 

Parameters:

(1) SAPS II score on admission (Simplified Acute Physiology Score)

(2) number of days between admission and initiaion of acyclovir therapy

 

Parameter	Finding	Points
SAPS II score on admission	< 27	0
	>= 27	1
number of days between admission and start of acyclovir therapy	<= 48 hours	0
	> 48 hours (> 2 days)	1

 

number of risk factors for a poor outcome =

= SUM(points for the 2 parameters)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 2

• The prognosis gets worse as the number of risk factors increase.

 

Additional factors identified on univariate analysis:

(1) development of a hospital-acquired infection

(2) lower Glasgow Coma Score (GCS) score