Sharma et al identified a number of prognostic factors affecting survival in a woman with advanced ovarian cancer. The authors are from the University of Sydney and the Imperial College London.
Patient selection: new diagnosis of Stage III or IV ovarian cancer
Parameters identified on multivariate analysis:
(1) Glasgow prognostic score (GPS), based on serum C-reactive protein and albumin
(2) tumor histology
(3) serum alkaline phosphatase
(4) initial surgery
|
Parameter |
Finding |
Points |
|
C-reactive protein (CRP) |
<= 10 mg/L |
0 |
|
|
> 10 mg/L |
1 |
|
albumin |
>= 35 g/L |
0 |
|
|
< 35 g/L (3.5 g/dL) |
1 |
Glasgow prognostic score = GPS =
= SUM(points for the 2 parameters)
|
Parameter |
Finding |
Points |
|
tumor histology |
serous |
0 |
|
|
non-serous |
1 |
|
serum alkaline phosphatase |
normal |
0 |
|
|
elevated |
1 |
|
initial surgery |
performed |
0 |
|
|
not performed |
1 |
number of other prognostic factors =
= SUM(points for the other 3 parameters)
Interpretation:
• The Glasgow Prognostic Score is a marker for systemic inflammation.
• The higher the GPS and the greater the number of other prognostic factors the worse the patient's overall survival.
Addiitional factors to consider from univariate analysis:
(1) poor performance status
(2) ascites
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
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