Zhang et al identified prognostic factors for an HIV-negative patient who develops Pneumocystis jirovecci pneumonia. These can help to identify a patient who may benefit from more aggressive management. The authors are from Second Military Medical Universtiy in Shanghai and Nanjing University.
Patient selection: HIV-negative with Pneumocystis jirovecii pneumonia
Risk factors in patient group:
(1) immunocompromising condition
(1a) hematologic malignancy
(1b) long-term systemic corticosteroids
(2) failure to receive prophylaxis
Risk factors for severe disease:
(1) age > 43 years
(2) dyspnea
(3) serum LDH > 404 U/L
Risk factors for mortality:
(1) serum LDH > 424 U/L
(2) PaO2 < 60 mm Hg
(3) absolute monocyte count < 0.2 * 10^9/L
(4) absolute lymphocyte count < 0.3 * 10^9/L
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