Stebbing et al developed a prognostic index for patients with AIDS-associated Kaposi's sarcoma. This can help make decisions about therapy in these patients. The authors are from Chelsea and Westminster Hospital in London.
Time for use: when Kaposi's sarcoma is first diagnosed
Parameters:
(1) age of the patient in years
(2) CD4 count per µL
(3) Kaposi's sarcoma as the AIDS defining illness
(4) presence of another AIDS-associated illness at the same time
Parameter
Finding
Points
age of the patient
< 50 years of age
0
>= 50 years of age
2
CD4 count per µL
(-1) * MIN(7, INT((CD4 count) / 100))
Kaposi's as AIDS definer
no
0
yes
-3
other AIDS illness
no
0
yes
3
where:
• To achieve the minimal score of 0, the maximum points for CD4 count must be (-7).
total score =
= SUM(points for all 4 parameters) + 10
Interpretation:
• minimum score: 0
• maximum score: 15
• The higher the score the worse the prognosis.
Total Score
Prognosis
5 Year Survival
< 5
good
78-95%
5 - 10
fair
60 - 80%
> 10
poor
50%
from Figure 4 (range from both primary cohort and validation set)
