Gang et al modified the International Prognostic Index (IPI) for patients with diffuse large B-cell lymphoma. The authors are from multiple institutions in Denmark.
Patient selection: diffuse large B-cell lymphoma
Outcome: overall survival
Parameters:
(1) age in years
(2) ECOG performance status
(3) serum LDH
(4) stage
(5) serum albumin in g/L
(6) number of extranodal sites
Parameter
Finding
Points
age in years
< 70 years
0
>= 70 years
1
ECOG performance
0 or 1
0
2 to 4
1
serum LDH
normal
0
elevated
1
stage
I or II
0
III or IV
1
serum albumin
> 40 g/L
0
<= 40 g/L
1
extranodal sites
<= 1
0
> 1
1
DLBCL-PI =
= (points for age) + (points for ECOG) + (points for LDH) + (points for stage) + (points for albumin)
age-adjusted DLBCL-PI for patients < 70 years of age =
= (points for ECOG) + (points for LDH) + (points for extranodal sites) + (points for albumin)
Interpretation:
• minimum scores: 0
• maximum DLBCL-PI: 5
• maximum age-adjusted DLBCL-PI: 4
DLBCL-PI
Risk Group
8-Year Survival
0 or 1
low
80%
2
low-intermediate
56%
3
high-intermediate
40%
4 or 5
high
27%
To read more or access our algorithms and calculators, please log in or register.
