Cao et al reported a prognostic model for a patient with liposarcoma. This can help to identify a patient who may benefit from more aggressive or a novel therapy. The authors are from Xi'AnJiatong University in China.
Patient selection: liposarcoma
Parameters:
(1) age in years
(2) sex
(3) site
(4) histology type
(5) grade
(6) surgery
(7) radiation therapy
(8) chemotherapy
(9) tumor size in cm
(10) extension
(11) first malignant
(12) marital status
(13) SES
(14) AJCC stage
points for age =
= 0.90909 * (age)
|
Parameter |
Finding |
Points |
|
sex |
male |
4.7 |
|
|
female |
0 |
|
site |
extremities |
0 |
|
|
other |
2.5 |
|
|
retroperitoneum |
2.7 |
|
histologic type |
well-differentiated |
0 |
|
|
NOS |
3.9 |
|
|
myxoid/round cell |
5.7 |
|
|
de-differentiated |
5.5 |
|
|
pleomorphic |
7.6 |
|
|
mixed-type |
12 |
|
grade |
I |
0 |
|
|
II |
7.3 |
|
|
III |
15.7 |
|
|
IV |
18.7 |
|
surgery |
yes |
0 |
|
|
no |
22.9 |
|
radiation therapy |
yes |
0 |
|
|
no |
5.5 |
|
chemotherapy |
yes |
10.7 |
|
|
no |
0 |
|
tumor size |
<= 5 cm |
0 |
|
|
5.01 to 10 cm |
3 |
|
|
> 10 cm |
8 |
|
extension |
confined |
0 |
|
|
localized |
2.3 |
|
|
adjacent connective tissue |
3.3 |
|
|
adjacent organ |
12.5 |
|
|
further (distant) |
16.1 |
|
first malignancy |
yes |
0 |
|
|
no |
6.7 |
|
marital status |
married |
0 |
|
|
single |
5.3 |
|
|
other |
2 |
|
socioeconomic status |
low |
0 |
|
|
medium |
2.3 |
|
|
high |
6.3 |
|
AJCC stage |
I |
4.1 |
|
|
II |
0 |
|
|
III |
6.9 |
|
|
IV |
25.1 |
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 257.3
value of X =
= (-0.00041888 * ((score)^2)) + (0.026479 * (score)) + 2.5005
5-year overall survival =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.79.
Specialty: Hematology Oncology
