Mo et al reported a nomogram for evaluating a patient with an unresectable hepatocellular carcinoma treated with dual PD-1 and angiogenesis blockade therapy. The authors are from multiple institutions in China.
LANS is an acronym for largest tumor size, AFP, neutrophil count, and spleen volume change
Patient selection: unresectable hepatocellular carcinoma treated with PD-1 and angiogenesis blockade
Parameters:
(1) diameter of largest tumor at baseline in mm
(2) serum AFP concentration at baseline in ng/mL
(3) absolute neutrophil count at C2 (6 weeks after treatment) in 10^9/L
(4) change in spleen volume at C2 (6 weeks atter treatment) in cubic cm (no data provided as to how it changed; it is assumed that it decreased in sze)
points for largest tumor =
= 1.111 * (diameter)
points for absolute neutrophil count =
= 5.2 * (ANC)
|
Parameter
|
Finding
|
Points
|
|
serum AFP at baseline
|
<= 20 ng/mL
|
0
|
|
|
20.1 to 400 ng/mL
|
61
|
|
|
> 400 ng/mL
|
70
|
|
change in spleen volume
|
< 20.05 cubic cm
|
0
|
|
|
>= 20.05
|
29.2
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 256.4
value of X =
= (-0.0002234 * ((score)^2)) + (0.004559 * (score)) + 2.841
probability of 2-year overall survival =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.87.
