Prognostic Model of Naqvi et al for a Patient with the Myelodysplastic Syndrome

Description

Naqvi et al developed a prognostic model for patients with the myelodysplastic syndrome (MDS). This incorporates the patient's comorbidity into a score for predicting overall survival. The authors are from the University of Texas M.D. Anderson Cancer Center in Houston.

Parameters:

(1) age in years

(2) comorbidity by the Adult Comorbidity Evaluation -27 (ACE-27)

(3) myelodysplasia IPSS

Parameter	Finding	Points
age in years	<= 65 years of age	0
	> 65 years of age	2
comorbidity	none	0
	mild or moderate	1
	severe	3
IPSS	low or intermediate-1	0
	intermediate-2	2
	high	3

where:

• Points were obtained by dividing the coefficients from the multivariate analysis by 0.3.

total score =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score: 8

• The higher the score the worse the survival.

Total Score	Risk Group	Median Survival	Percent Survival at 4 Years
0 or 1	low	43 months	45%
2 to 4	intermediate	23 months	24%
5 to 8	high	9 months	6%

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Description

Specialty

ICD-10