Prognostic Score of Patnaik et al for Refractory Anemia with Ringed Sideroblasts and Thrombocytosis (RARS-T, Myelodysplastic/Myeloproliferative Neoplasm with Ringed Sideroblasts and Thrombocytosis, MDS/MPN-RS-T)
Patnaik et al reported a prognostic score for a patient with Myelodysplastic/Myeloproliferative Neoplasm with Ringed Sideroblasts and Thrombocytosis (MDS/MPN-RS-T). The authors are from the Mayo Clinic.
Former designation: Refractory Anemia with Ringed Sideroblasts and Thrombocytosis (RARS-T)
Parameters associated with worse survival:
(1) anemia (hemoglobin < 10 g/dL)
(2) abnormal karyotype
(3) presence of ASXL1 and/or SETBP1 mutations
Parameter
Finding
Points
anemia
absent
0
present
1
abnormal karyotype
no
0
yes
2
ASXL1 and/or SETBP1 mutations
no
0
yes
1
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
Score
Risk Group
Median Survival
0
low
80 months
1
intermediate
42 months
2 to 4
high
11 months
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