Prognostic Score of Regierer et al for Metastatic Breast Cancer

Description

Regierer et al reported a prognostic score for a woman with metastatic breast cancer. This can help to identify a woman who may benefit from more aggressive or novel therapy. The authors are from Charite Universitatsmedizin Berlin, University of Bremen, Klinikum Oldenburg and Medical University of Graz.

Patient selection: metastatic breast cancer

Parameters:

(1) metastasis-free interval in years

(2) hormone receptor (estrogen, progesterone)

(3) liver metastases

(4) brain metastases

(5) bone metastases

(6) bone marrow metastases

(7) soft tissue metastases

(8) lung metastases

(9) malignant effusion (associated with metastases)

Parameter	Finding	Points
metastasis-free interval	> 2 years	0
	<= 2 years	3
hormone receptors	absent	0
	present	8
liver metastases	absent	0
	present	7
brain metastases	absent	0
	present	8
bone metastases	absent	0
	present	4
bone marrow metastases	absent	0
	present	10
soft tissue metastases	absent	0
	present	4
lung metastases	absent	0
	present	4
malignant effusion	absent	0
	present	4

total score =

= SUM(points for all 9 parameters)

Interpretation:

• minimum score: 0

• maximum score: 52

• The higher the score the greater the risk.

Total Score	Risk Group	5-Year Overall Survival
0 to 8	low	51%
9 to 14	intermediate	31%
>= 15	high	12%

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Prognostic Score of Regierer et al for Metastatic Breast Cancer

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