Cornec-Le Gall et al reported the PROPKD score for predicting renal survival for a patient with autosomal dominant polycystic kidney disease (ADPKD). The authors are from multiple institutions in France.
Outcome: renal survival (vs end-stage renal disease, ESRD)
Parameters:
(1) sex
(2) hypertension before age 35 years
(3) number of urologic events before age 35 years (gross hematuria, cyst hemorrhages, cust infection, flank pain related to cysts)
(4) mutation
Parameter
Finding
Points
sex
female
0
male
1
hypertension before 35 years
no
0
yes
2
urologic events before 35 years
0
0
>= 1
2
mutation
PKD2
0
PKD1 nontruncating
2
PKD1 truncating
4
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 9
• The higher the score the greater the risk of ESRD.
Total Score
Risk Group for ESRD
Median Age ESRD
0 to 3
low
70.6
4 to 6
intermediate
56.9
7 to 9
high
49
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