Troost et al evaluated various cutoffs of proteinuria as a predictor for remission in focal segmental glomerulosclerosis (FSGS). Achieving a partial or complete remission is better than no remission at all.
Patient selection: focal segmental glomerulosclerosis (FSGS)
Outcome: progression to end-stage renal disease (ESRD)
Level of Proteinuria
Conventional Criteria
< 0.3 g per g creatinine
complete remission
0.3 to < 3.5 g per g creatinine and >= 50% reduction in proteinuria
partial remission
Level of Proteinuria
"Novel" Criteria
< 0.3 g per g creatinine
complete remission
0.3 to < 1.5 g per g creatinine and >= 40% reduction in proteinuria
partial remission
Novel Criteria at 4 Months
ESRD
complete remission
3 of 30 (10%)
novel partial remission
17 of 94 (18%)
novel no response
44 of 163 (27%)
Conventional Criteria at 4 Months
ESRD
complete remission
3 of 30 (10%)
partial remission
24 of 114 (21%)
no response
37 of 143 (26%)
Novel Criteria at 8 Months
ESRD
complete remission
6 of 41 (15%)
partial remission
13 of 71 (18%)
no response
51 of 116 (44%)
Conventional Criteria at 8 Months
ESRD
complete remission
6 of 41 (15%)
partial remission
19 of 85 (22%)
no response
45 of 104 (43%)
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