Recurrence Risk Formula (RRF) of Cindolo et al for Predicting the Risk of Recurrence in a Patient with Nonmetastatic Renal Cell Carcinoma

 

NOTE: The score uses the same parameters as the model of Yaycioglu et al (above).

 

Patient selection: nonmetastatic renal cell carcinoma who underwent a nephrectomy

 

Parameters:

(1) clinical symptom status at diagnosis

(2) maximum diameter of the tumor

 

Clinical symptoms included:

(1) acute flank pain

(2) lumbar pain

(3) palpable mass

(4) hematuria

(5) anemia

(6) weight loss

(7) asthenia

(8) hypercalcemia

 

Clinical Symptoms	Points
absent	0
any present	1

 

recurrence risk formula =

= (1.28 * (points for symptom status)) + (0.13 * (maximum diameter in cm))

 

Interpretation:

• The minimum score is probably around 0.01.

• The maximum score is probably around 3.0.

• A score > 1.2 was considered high risk for recurrence.

• To get a high risk score, either the patient is symptomatic at presentation or the tumor measures > 9.2 cm.

 

Score	Risk Group	Risk of Recurrence at 2 Years	Risk of Recurrence at 5 Years
<= 1.2	low	0.96	0.93
> 1.2	high	0.83	0.68