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Renal Cell Carcinoma | UCLA Integrated Staging System (UISS)

Purpose: To predict the survival for a patient with renal cell carcinoma using the UCLA Integrated Staging System (UISS).

Description

The UCLA Integrated Staging System (UISS) for renal cell carcinoma combines tumor stage, histologic grade and patient performance status into a single value that correlates with survival. The UISS is simple to use and predicts patient survival better than the TNM stage alone. The system was developed by urologists at UCLA in Los Angeles.


 

Parameters:

(1) TNM stage, using the revised 1997 criteria

(2) Fuhrman grade (from 1 to 4)

(3) ECOG performance (from 0 to 4)

1997 TNM Stage

Fuhrman's Grade

ECOG Performance Status

UISS Stage

I

1, 2

0

I

I

1, 2

1, 2, 3, 4

II

I

3, 4

0, 1, 2, 3, 4

II

II

1, 2, 3, 4

0, 1, 2, 3, 4

II

III

1, 2, 3, 4

0

II

III

1

1, 2, 3, 4

II

III

2, 3, 4

1, 2, 3, 4

III

IV

1, 2

0

III

IV

3, 4

0

IV

IV

1, 2, 3

1, 2, 3, 4

IV

IV

4

1, 2, 3, 4

V

 

where:

• I am not sure how often a person with a TNM Stage of I or II would have an ECOG performance Status of 4.

 

UISS Stage

2 Year Survival (SE)

5 Year Survival (SE)

I

96% (2.5)

94% (2.5)

II

89% (3.8)

67% (6.4)

III

66% (6.5)

39% (2.8)

IV

42% (3.5)

23% (3.1)

V

9% (6.2)

0% (4.0)

SE = standard error

 


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Specialty

Objective

ICD-10