The response of a patient with Langerhans Cell Histiocytosis (LCH) to therapy can be classified into semi-quantitative categories (LCH III).
Patient selection: Langerhans Cell Histiocytosis ay 6 weeks after therapy
General Category |
Response |
Alternative |
better |
complete resolution |
non-active |
better |
regression |
active disease-better |
interrmediate |
mixed |
active-mixed |
intermediate |
stable |
active-unchanged |
worse |
worse |
active disease-worse |
Mixed: regression in one site AND progression in another
Stable: neither regression nor progression
Worse: progression of signs and symptoms and/or appearance of new lesions
Existing Lesions |
New Lesions |
Signs and Symptoms |
Response |
inactive |
none |
none |
non-active |
regression |
none |
better |
active-better |
regression |
present |
unchanged |
active-mixed |
unchanged |
none |
unchanged |
active-unchanged |
progression |
NA |
progression |
active-worse |
unchanged |
present |
progression |
active-worse |
Specialty: Hematology Oncology