Reverse Sequestration in Sickle Cell Anemia

A patient with acute sequestration in sickle cell anemia may develop reverse sequestration if the red blood cells re-enter the circulation.

Clinical features:

(1) patient with sickle cell anemia and acute sequestration syndrome

(2) rapid rise in hemoglobin over 24-48 hours

(2) sudden expansion of the blood volume, which can result in heart failure, hypertension and stroke

Risk factors for complications:

(1) multiple transfusions in a patient with acute sequestration

(2) pre-existing cardiac disease

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