Patient selection: liver transplantation waiting list
Outcome: 90-day mortality
Parameters:
(1) serum total bilirubin in mg/dL
(2) serum creatinine in mg/dL
(3) INR
(4) serum sodium in mmol/L
Constraints on parameters:
(1) minimum bilirubin: 1 mg/dL
(2) maximum bilirubin for combined factor with sodium: 20 mg/dL
(3) minimum creatinine: 0.8 mg/dL
(4) maximum creatinine: 3 mg/dL
(5) minimum INR 1
(6) maximum INR: 3
(7) minimum sodium: 125 mmol/L
(8) maximum sodium: 140 mmol/L
Other adjustments: renal replacement therapy defined as creatinine of 3 mg/dL
refitted MELD score =
= (4.258 * LN(bilirubin)) + (6.792 * LN (creatinine)) + (8.29 * LN(INR)) + (0.652 * (140 - (sodium))) - (0.194 * (140 - (sodium)) * (bilirubin)) + 6.327
