Mechanism: necrosis of the mid-epidermis with a collection of interstitial fluid
Risk factors for friction blisters:
(1) exposure to moisture or sweat
(2) hot environment (more likely to be active, with increased sweating)
(3) repeated abrasions of the skin
(4) lack of skin conditioning (smooth skin with no calluses)
(5) edema
(6) pre-existing skin inflammation
Complications:
(1) pain with impaired function
(2) bleeding with continued use
(3) secondary infection
Protection:
(1) gloves
(2) properly fitting shoes
(3) keeping the skin dry, especially on the feet. This may include 2 or more kinds of socks, with a thin polyester inner sock to wick away moisture and a thicker wool sock to provide cushioning.