Isoniazid (INH) is a potential hepatotoxin that can cause serious drug-induced hepatitis, which can be fatal.
Risk factors for isoniazid-induced hepatotoxicity:
(1) chronic alcohol abuse
(2) other chronic liver disease (nonalcoholic steatohepatitis, chronic viral hepatitis C, etc)
(3) slow acetylator status (associated with impaired INH metabolism, see 32.31.01)
(4) high dose
(5) intake with drugs that interfere with metabolism such as phenobarbital, rifampin and para-aminosalicylic acid (PAS)
(6) intake of drugs that are potentially hepatotoxic such as acetaminophen
(6) adults >= 50 years of age
(7) malnutrition
(8) pregnant female
where:
• The risk is usually very low for patients < 20 years of age and low for patients 20 to 34 years of age.
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Purpose: To identify risk factors for drug-induced hepatotoxicity in a patient taking isoniazid (INH).
Specialty: Toxicology, Emergency Medicine, Critical Care, Infectious Diseases
Objective: risk factors, adverse effects
ICD-10: T37.1,
